Researcher at the University of Leipzig and Vanderbilt University have published an interesting paper [Front. Mol. Biosci. (2023), 10, 1121962] that describes a new AlphaFold pipeline to model GPCRs and kinases with user-defined conformational states.

Users can specify which GPCR activation state (Active, Inactive, Intermediate) or kinase structural features (DFG=out, Ac_H=out) they want and the script will predict the desired characteristics. Their code works with ColabFold and is available on GitHub (meilerlab/AF2_GPCR_Kinase).